A Clinical Study of Keratocystic Odontogenic Tumors

Keratocystic Odontogenic Tumors – Clinical and Molecular Features

Keratocystic odontogenic tumors (KCOTs) are certainly among the most studied lesions in oral pathology, which is not a surprise considering their perplexing clinical behavior and complicated mechanism of pathogenesis. In fact, the specific KCOT features are the reason for numerous discussions regarding the true nature and classification of these lesions, which are still debated in the scientifi...

Smoothened gene alterations in keratocystic odontogenic tumors

BACKGROUND It has been widely demonstrated that the hedgehog pathway is strongly associated with basal cell carcinoma of the skin (NBCCS). To assess potential DNA alterations related to keratocystic odontogenic tumors (KCOTs), we sequenced smoothened (SMO) genes in 12 sporadic KCOTs. METHODS Polymerase chain reaction (PCR), capillary electrophoresis and dideoxy chain-termination sequencing we...

Li Gene Alterations in Keratocystic Odontogenic Tumors

Removal of Multiple Keratocystic Odontogenic Tumors in a Nonsyndromic Patient

Multiple keratocystic odontogenic tumors are one of the key features of Gorlin-Goltz syndrome. A 15-year-old nonsyndromic female child presented with multiple keratocystic odontogenic tumors. The presence of the tumors was observed in immunological examinations. The images led to the suspicion of Gorlin-Goltz syndrome which was discarded after analyzing the patient's medical history and complem...

Endoscopic resection of maxillary sinus keratocystic odontogenic tumors.

INTRODUCTION Modified endoscopic approaches allow for complete excision of maxillary keratocystic odontogenic tumors (KCOTs), with significantly decreased morbidity compared to open approaches. Formerly odontogenic keratocysts, KCOTs were reclassified by the World Health Organization in 2005 due to their aggressive and locally destructive nature. These tumors arise from the dental lamina or bas...